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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: many challenges in developing efficient and target specific delivery systems of small molecule and nucleic

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 203-212 doi: 10.1007/s11705-016-1572-4

Abstract: Modeling structural and thermodynamic properties of nucleic acids has long been a challenge in the developmenthave been proved to be reliable to model small molecules, polypeptides and proteins, but their use on nucleicIn this article, the interactions between nucleic acids and a small molecule or ion were modeled by AMOEBAbio09

Keywords： nucleic acid     polarizable force field     AMOEBA    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryengineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleicacids and protein-nucleic acid complexes.Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids(SeNA) for nucleic acid crystallography.

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleic

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0884-4

Abstract: Flow cytometry based on nucleic acid stains and CTC was established and optimized.Chlorine demonstrated stronger and faster destructive effects on cytomembrane than chloramine, and nucleic

Keywords： Flow cytometry     Escherichia coli     Staphylococcusaureus     UV     CTC     SYTO 9    

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Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 173-186 doi: 10.1007/s11684-012-0195-5

Abstract: Nucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequencesHere we review some of the most popular nucleic acid-based diagnostics and focus on their adaptabilityWe also compare and contrast the characteristics of different types of nucleic acid-based diagnostics

Keywords： nucleic acid-based diagnostics     infectious disease     PCR     NASBA     LAMP     microarray     LOAC     public health affairs    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: Considering the urgent needs of coronavirus disease 2019 (COVID-19) epidemic prevention and control, nucleicThis article first summarizes the R&D status of nucleic acid vaccines from the aspects of relatedtechnical concept, R&D path, and development trend, and identifies the characteristics of nucleicFurthermore, we suggest that the key technologies of nucleic acid vaccines should be developed by improvingMoreover, the safety and efficacy of nucleic acid vaccines should be strictly monitored; stakeholders

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messenger    

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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 213-221 doi: 10.1007/s11705-015-1541-3

Abstract: been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic

Keywords： methide     DNA alkylation     reversible covalent reaction     bioconjugation     target-directed modification of nucleic    

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Development Strategy of Microbial Safety Industry

Song Zhongjian, Li Man, Hu Liangbin, Wang Chunming, Lu Xi, Liu Kaihui, Zhang Lijia, Yu Yan, Wu Qingping

Strategic Study of CAE 2021, Volume 23, Issue 5,   Pages 79-85 doi: 10.15302/J-SSCAE-2021.05.010

Abstract:

Microbial safety is crucial for China’s social and economic development in the new era, and it is an important support for national food security, public health, and social stability. In this article, we analyze the development needs and current status of the microbial safety industry considering the policy environment in China. Subsequently, we clarify the domestic and global development patterns of the industry and summarize the challenges faced by the innovation and application of pathogenic microorganism detection and control technologies in China. Furthermore, we propose a development plan for building China’s microbial safety industry. To explore a high-quality development path, China should build innovation platforms and a large scientific database regarding microbial safety, enhance personnel development for this industry, encourage leading enterprises to develop according to standards and regulations, and strengthen major system innovation and engineering technology research in the microbial safety field.

Keywords： microbial safety     microbial detection     microbial diagnosis     microbial prevention and control     nucleic    

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Research Progress in Molecular Identification Technology for Microbial Resources

Zhang Yu, Ma Aijin, Gao Lifen, Peng Hai, Jia Yingmin, Sun Baoguo

Strategic Study of CAE 2021, Volume 23, Issue 5,   Pages 86-93 doi: 10.15302/J-SSCAE-2021.05.011

Abstract: China and abroad; these technologies include deoxyribonucleic acid (DNA) (G+C) mol% identification, nucleicacid hybridization, DNA fingerprinting, nucleic acid amplification, gene chips, and high throughput

Keywords： microbial resources     molecular identification     nucleic acid amplification technique     gene chip technology    

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Rapid Detection of Wheat Blast Pathogen Magnaporthe Oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology Article

Houxiang Kang, Ye Peng, Kangyu Hua, Yufei Deng, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, Yilin Zhou, Xueping Zhou, Md Tofazzal Islam, Guo-Liang Wang

Engineering 2021, Volume 7, Issue 9,   Pages 1326-1335 doi: 10.1016/j.eng.2020.07.016

Abstract: combined target-dependent Cas12a ssDNase activation with recombinase polymerase amplification (RPA) and nucleic

Keywords： Wheat blast     Magnaporthe oryzae     Triticum Cas12a     Nucleic acid rapid lateral flow immunoassay     Field    

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A High-Throughput, Multi-Index Isothermal Amplification Platform for Rapid Detection of 19 Types of Common Respiratory Viruses Including SARS-CoV-2 Article

Wanli Xing, Yingying Liu, Huili Wang, Shanglin Li, Yongping Lin, Lei Chen, Yan Zhao, Shuang Chao, Xiaolan Huang, Shaolin Ge, Tao Deng, Tian Zhao, Baolian Li, Hanbo Wang, Lei Wang, Yunpeng Song, Ronghua Jin, Jianxing He, Xiuying Zhao, Peng Liu, Weimin Li, Jing Cheng

Engineering 2020, Volume 6, Issue 10,   Pages 1130-1140 doi: 10.1016/j.eng.2020.07.015

Abstract: Here, we present a high-throughput, multi-index nucleic acid isothermal amplification analyzer (RTisochip

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus 2     Microfluidics     Nucleic acid    

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Title Author Date Type Operation

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Journal Article

Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleic

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Journal Article

Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Journal Article

Development Strategy of Microbial Safety Industry

Song Zhongjian, Li Man, Hu Liangbin, Wang Chunming, Lu Xi, Liu Kaihui, Zhang Lijia, Yu Yan, Wu Qingping

Journal Article

Research Progress in Molecular Identification Technology for Microbial Resources

Zhang Yu, Ma Aijin, Gao Lifen, Peng Hai, Jia Yingmin, Sun Baoguo

Journal Article

Li Aihua: Development Trends and Suggestions of Nucleic Acid Vaccines (2021-9-3)

15 Oct 2021

Conference Videos

Rapid Detection of Wheat Blast Pathogen Magnaporthe Oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology

Houxiang Kang, Ye Peng, Kangyu Hua, Yufei Deng, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, Yilin Zhou, Xueping Zhou, Md Tofazzal Islam, Guo-Liang Wang

Journal Article

A High-Throughput, Multi-Index Isothermal Amplification Platform for Rapid Detection of 19 Types of Common Respiratory Viruses Including SARS-CoV-2

Wanli Xing, Yingying Liu, Huili Wang, Shanglin Li, Yongping Lin, Lei Chen, Yan Zhao, Shuang Chao, Xiaolan Huang, Shaolin Ge, Tao Deng, Tian Zhao, Baolian Li, Hanbo Wang, Lei Wang, Yunpeng Song, Ronghua Jin, Jianxing He, Xiuying Zhao, Peng Liu, Weimin Li, Jing Cheng

Journal Article